what is anadrol

Currently there are no data on the effects against what is anadrol fertility simeprevira humans. Studies in animals revealed no effects against fertility. In studies in rats and mice at doses of 0.5 times (in rats) and 6-fold (mice) exceeding the recommended average daily dose (150 mg), was not observed simeprevira teratogenicity.

In embriofetalnyh studies in mice at doses up to 1000 mg / kg, simeprevir induced early and late death of embryos in utero , and early mortality when receiving maternal doses at about 6 times the recommended daily dose. A significant reduction in fetal weight and an increased number of bone changes observed when receiving doses approximately 4 times higher than the recommended daily dose.

The pre- and post-natal rat studies simeprevir taken in doses up to 1000 mg / kg / day during gestation and lactation. In pregnant rats simeprevir caused early mortality when receiving a dose of 1000 mg / kg / day. A significant reduction in weight gain rate was observed at doses from receiving 500 mg / kg / day. With the development of the offspring what is anadrol of rats treated during pregnancy or lactation simeprevira dose approximately equal to the recommended daily dose, there was a decrease in body weight and negative effects on growth (delayed physical development and a decrease in body size) and development (reduced physical activity). Subsequent survival, behavior, and fertility were not changed.

Dosing and Administration

The recommended dose of the drug Sovriad – one capsule (150 mg) into 1 time per day during the meal. The type of food does not influence the pharmacokinetic parameters simeprevira. The capsules should be swallowed whole.

Sovriad The drug should not be used as monotherapy.

Sovriad should be used in combination with peginterferon alfa and ribavirin.

Information on the application and doses of peginterferon alfa and ribavirin is given in the respective instructions for use. 

Correction of the dose or suspend treatment

In order to avoid treatment failure is not allowed to reduce the dose or discontinue therapy drug Sovriad. In the event of discontinuation Sovriad drug because of adverse reactions or inadequate virologic response resumption of therapy with this drug is not allowed.

In case of adverse reaction potentially related to peginterferon alfa and ribavirin, and require dose adjustment or stop treatment with any of these drugs should be guided by the instructions set out in the instructions for use of the medication.

skipping doses

If the delay in receiving the drug Sovriad drug what is anadrol was less than 12 hours, the missed dose should be taken as soon as possible with food and resume the normal dosing schedule.

If the delay in receiving the drug Sovriad was more than 12 hours, the missed dose should not be accepted; the next dose is taken at the usual time.

Children and adolescents (under 18 years)

The safety and efficacy of medicinal Sovriad drug in children and adolescents has not been studied.

Elderly patients (over 65 years)

Data what is anadrol on the safety and efficacy of the medicinal product Sovriad in patients older than 65 years are limited. No dose adjustment in elderly patients is not required.