Like other antipsychotics: Amisulpride causes an increase in the level of prolactin in the blood plasma, which is returned to its previous value after discontinuation of the drug. This anadrol steroid may cause galactorrhea, amenorrhea, gynecomastia, breast pain, impotence and weight gain.
It may develop acute dystonia (spasmodic torticollis, oculogyric crises, lockjaw). This state is reversible and is adjusted by means of anti-Parkinsonian agents. The incidence of extrapyramidal symptoms, which depend on the dose, remains very low in the treatment of patients with predominantly negative symptoms doses of 50 -. 300 mg / day
messages of tardive dyskinesia characterized by rhythmical, involuntary movements mainly language and / or persons are usually in cases of long-term use of the drug. Antiparkinsonian agents are ineffective, they may cause a worsening of symptoms.
In rare cases, may develop hypotension and bradycardia, as well as lengthening the interval QT, very rarely -. Atrial fibrillation
Occasionally reports of allergic reactions, increased liver enzymes, mainly transaminases and cases of convulsive seizures.
There are very rare reports of neuroleptic malignant syndrome (see. “Special instructions”).
Experience with Amisulpride overdose is limited. It is reported to strengthen the known pharmacological effects of the drug. These include drowsiness and sedation, coma, hypotension and extrapyramidal symptoms.
In cases of acute overdose should suggest the possibility of an interaction of several drugs.
The specific antidote to amisulpride does not exist. Treatment is symptomatic, it is recommended strict monitoring of vital functions and continuous monitoring of heart condition (risk of prolongation of the QT interval) until the restoration of the patient’s condition. Hemodialysis is anadrol steroid not effective.
In case of severe extrapyramidal symptoms, anticholinergic agents should be appointed.
Interaction with other drugs
Contraindicated in combination
combinations that can cause ventricular arrhythmias such as “pirouette”:
- Class Ia antiarrhythmic drugs such as quinidine, disopyramide.
- Class III antiarrhythmic drugs such as amiodarone, sotalol.
- Other medications such as bepridil, cisapride, sultopride, thioridazine, intravenous erythromycin, intravenous vincamine, halofantrine, pentamidine, sparfloxacin.
Levodopa: reciprocal antagonism of the action of levodopa and neuroleptics.
Not recommended combinations
Amisulpride dampening effect on the central nervous system of alcohol.
Combinations requiring special care
medicaments, enhancing the risk of ventricular arrhythmias such as “pirouette”:
Drugs that cause bradycardia, such as beta-blockers, calcium channel blockers, which induce bradycardia (verapamil and diltiazem), clonidine, guanfacine; digitalis drugs.
Drugs that can cause hypokalaemia: anadrol steroid potassium carve diuretics, laxatives, amphotericin B, glucocorticoids, tetrakozaktid (hypokalemia should be corrected).
Neuroleptics such as pimozide, haloperidol; antidepressants such as imipramine; lithium.
Combinations to be taken into account the
combination with drugs depressing the central nervous system function, including narcotic analgesics, antipsychotics (neuroleptics), antihistamines with sedative effect, barbiturates, benzodiazepines and other anxiolytic drugs, expressed increased inhibitory action. With antihypertensive drugs – increased antihypertensive effect.