Levels of hepatitis C virus should be assessed at 4 and 12 weeks as clinically indicated. For monitoring of hepatitis C virus anadrol cycle levels during therapy is recommended to use a sensitive quantitative analysis .
Requirements for the source and received during and after the treatment the results of general clinical blood analysis, biochemical blood tests (including tests of liver enzymes and bilirubin) and pregnancy tests are given in the instructions on the use of peginterferon alfa and ribavirin.
Use in patients after the ineffectiveness of previous therapy with antivirals direct acting anti-viral hepatitis C
Safety and effectiveness in patients after simeprevira ineffectiveness of previous therapy simeprevirom or other antivirals direct action for the treatment of hepatitis C has not been studied.
The use in patients with other genotypes of hepatitis C virus
Currently, there is insufficient clinical data to support the use of medicinal Sovriad drug in patients with hepatitis C genotypes 2, 3, 5 or 6, so Sovriad drug should not be used in these patients.
Interactions with drugs
The combined use of the drug with drugs that provide a strong or moderate inducing or inhibiting effect in respect of isoenzyme, is not recommended because it can lead to a significant reduction or increase simeprevira concentration.
The combined use with other antiviral drugs direct action for the treatment of hepatitis C
Data on joint use of the drug anadrol cycle with telaprevir or boceprevir absent. It is assumed that these protease inhibitors of hepatitis C virus may show cross-resistance. their combined use is not recommended in this connection.
Use in combination with peginterferon alfa-2b
In clinical studies in patients receiving simeprevir in combination with peginterferon alfa-2b and ribavirin, UVO12 indicators were slightly lower, often resulting increase in viral load and recurrence of viremia, compared with patients receiving therapy simeprevirom in combination with peginterferon alfa-2a and ribavirin.
Co-infection with hepatitis B virus
The safety and efficacy simeprevira during therapy of hepatitis C in patients coinfected with hepatitis B, has not been studied.
The safety and efficacy simeprevira in patients after organ transplantation has not been studied.
The combined use of cyclosporine is not recommended drug, so in this case may significantly increase the concentration simeprevira.
Photosensitivity reactions (which were mostly mild to moderate) have been observed in patients receiving treatment with Sovriad in combination with peginterferon alfa and ribavirin.
It is necessary to use adequate sun protection during therapy with S in combination with peginterferon alfa and ribavirin. Using tools to enhance tanning, and prolonged exposure to direct sunlight is contraindicated during therapy with Sovriad in combination with peginterferon alfa and ribavirin. In case of photosensitivity reactions need to consider the appropriateness of drug discontinuation Sovriad and carry out a thorough monitoring of patients before the disappearance of photosensitivity reactions.
The rash was observed in patients receiving therapy with Sovriad in combination with peginterferon alfa and ribavirin. The rash appears most often in the first 4 weeks of therapy, but its appearance is possible at any time during treatment. Also, there was a rash and severe rashes requiring drug discontinuation Sovriad. Most often it observed a rash of mild or moderate. Patients anadrol cycle with mild to moderate rash degree should be under the supervision of a physician for possible progression of rash, including the development of mucosal lesions (eg, lesions of the mucous membranes of the mouth, conjunctivitis) or systemic manifestations. If the rash becomes severe, therapy with Sovriad should be abolished. Patients should be monitored carefully as long as the manifestation of the rash disappears.