The size of the lipid globules anadrol 50 administered with the emulsion, and biological properties identical to those of physiological chylomicrons in the blood.
Full or partial parenteral nutrition as a source of energy and essential fatty acids, including w-3 fatty acids, when oral or enteral nutrition is impossible, insufficient or contraindicated.
prevention and treatment failure (deficit) of essential fatty acids, including the ω-3 fatty acids.
- Known hypersensitivity to the fish, egg or soy protein or to the drug.
- Severe hyperlipidemia
- Severe hepatic insufficiency
General contraindications for parenteral nutrition:
- Heavy nekorrigiruemye coagulation disorders
- Severe renal insufficiency without the possibility to perform hemodialysis, hemofiltration or
- General contraindications to infusion therapy: acute pulmonary edema, hyperhydration, decompensated cardiac insufficiency
- Unstable condition (acute myocardial infarction, stroke, anadrol 50 embolism, severe metabolic acidosis, hypotonic dehydration).
Pregnancy, lactation and childhood
special controlled clinical studies on the use during pregnancy, lactation and in children has not been, so the use of the drug in these patients is possible with careful assessment of risk / benefit.
SMOFlipid should be administered with caution in conditions characterized by impaired lipid metabolism, which may occur in patients with renal insufficiency, diabetes mellitus, pancreatitis, severe hepatic insufficiency, hypothyroidism.
Dosage and administration
for infusion into the central or peripheral vein. The dose and infusion rate should be determined by the patient’s ability to eliminate lipids introduced intravenously (see “Special precautions”).
The standard dose is 1-2 g fat / kg body weight / day, corresponding to 5-10 ml of the drug / kg / day.
The maximum daily dose: 2 g fat / kg / day, which corresponds to 10 ml of the drug / kg / day.
The recommended infusion rate is 0.125 g fat / kg body weight / h, which corresponds SMOFlipid 0.63 ml / kg body weight / h. The infusion rate should not exceed 0.15 g fat / kg body weight / h, which corresponds SMOFlipid 0.75 ml / kg body weight / h.
Rare: slight fever, chills, nausea, decreased anadrol 50 appetite (less than 1%). Very rare: hypersensitivity reactions (eg anaphylactic reaction, skin rash, urticaria, flushing, headache), sensation of heat or cold, paleness, cyanosis, pain in the neck, back, chest, back pain, hypotension, hypertension, shortness of breath (less than 0.1%)
Once these side effects occur or triglyceride levels during infusion over 4 mmol / l, the introduction of any fat emulsion should be stopped or, if necessary, to continue its lower injection rate.
Reduced ability to eliminate triglycerides may lead to a “fat overloading syndrome”, which may be caused by an overdose of any fat emulsions. We should be monitored for possible signs of metabolic overload. The reason may be genetic (individual difference metabolism), or exchange of fat may affect ongoing or previous condition. This syndrome may also develop during severe hypertriglyceridemia, even at the recommended infusion rate, and accompanied by a sudden change in the patient’s clinical condition, such as the appearance of renal failure or acquisition of infection. Fat overload syndrome is characterized by hyperlipemia, fever, fat infiltration, hepatomegaly with or without icterus, splenomegaly, leukopenia, thrombocytopenia, coagulation disorders, hemolysis, reticulocytosis, abnormal results of liver function tests and development of coma. Termination of infusion of a fat emulsion leads to disappearance of all symptoms.
The interaction with other drugs.
The use of heparin in clinical doses causes a transient increase in lipoprotein secretion into the bloodstream. Initially, this can lead to increased plasma lipolysis followed by a temporary decrease triglyceride clearance. Soybean oil is a natural source of vitamin K1. However, the content of this vitamin in has no significant effect on the process of blood clotting in patients treated with coumarin derivatives. Can be mixed with preparations of fat-soluble vitamins (Vitalipid) and water-soluble vitamins (Soluvit).
When SMOFlipid assigned with other infusion fluids (eg, amino acid solutions, glucose solutions) through a conventional system for intravenous infusion, it should be guaranteed compatibility of solutions and emulsions.
The ability to eliminate fat is individual and, therefore, recommended to control the level of triglycerides. When introducing any fat emulsions concentration of triglycerides in blood serum during infusion should not exceed 4.3 mmol / l.
The excess of only the medium chain fatty acids can lead to metabolic acidosis. This risk is considerably reduced when applying anadrol 50 by reducing the proportion of medium-chain fatty acids and simultaneous introduction of long chain fatty acids. If parenteral nutrition is recommended that simultaneous administration of carbohydrates as an energy source.